Polyaminecarboxylateruthenium(III) complexes on the mosaic of bioinorganic reactions. Kinetic and mechanistic impact

Ru-pac complexes (pac = polyaminecarboxylate) are prospective in many ways for biological applications. They have unique features that make them suitable for biological applications. For instance, Ru-pac complexes can bind to biomolecules through a rapid and facile aqua-ligand substitution reaction and have a range of accessible and stable oxidation states. Ru-pac complexes also have some notable catalytic properties that mimic the enzymatic hydrocarbon oxidation by cytochrome P450 under homogeneous conditions, which is of immense significance toward developing Ru-pac-based agents for oxidative cleavage of DNA and artificial nuclease in DNA footprinting experiments. The advancement of Ru-pac-mediated bioinorganic reactions in terms of unraveling the mechanistic information has not been systematically reviewed till date. Hence, the subject of this review comprises mostly kinetic and mechanistic studies of bioinorganic reactions involving Ru-pac complexes. This review highlights the mechanistic aspects of recent investigations on the reactions of Ru-pac complexes that emphasize the prospect of the biological application of such complexes and ascertain the likely mechanisms of action of the Ru-pac complexes in some bioinorganic processes.