Synthesis and biological activity of cinnamaldehydes as angiogenesis inhibitors

Authors :: Soo-Ik Chang
Byoung Mog Kwon
Song Hae Bok
Young Kwon Cho
Seung Ho Lee
Mi Ran Youn
Seung Ho So
Source :: Bioorganic & Medicinal Chemistry Letters. 7:2473-2476
Publication Year :: 1997
Publisher :: Elsevier BV, 1997.
Abstract: A series of 2-hydroxycinnamaldehyde derivatives was synthesized for examing a structure-activity relationship for inhibition of angiogenesis. The anti-angiogenic effects of 2′-substituted cinnamaldehdes and related analogs were determined in a chick embryo chorioallantoic membrane assay system.

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