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Subacute co-exposure to low doses of ruthenium(III) changes the distribution, excretion and biological effects of silver ions in rats

Authors :
Felicia Loghin
Cristian Berce
Ionel Fizesan
Cezara Voica
Maria-Georgia Stefan
Carmen Georgiu
Ramona Simedrea
Marius Emil Rusu
Béla Kiss
Dana Alina Magdas
Oliviu Vostinaru
Rodica Boros
N. Vedeanu
Adriana Grozav
Daniela-Saveta Popa
Source :
Environmental Chemistry. 17:163
Publication Year :
2020
Publisher :
CSIRO Publishing, 2020.

Abstract

Environmental contextAlthough ruthenium is a technology-critical element used in several new industries, little is known about its environmental impact or possible human health risks. We report a toxicological evaluation of laboratory animals during co-exposure to ruthenium and silver. We identified interactions between the two elements that could lead to unwanted biological effects. AbstractRuthenium is one of the rarest metals on Earth that is classified as a technology-critical element (TCE). Silver, however, is well known for its antibacterial and immunostimulant properties. The increasing use of Ru and Ag in medicine and daily life makes simultaneous exposure possible, with unknown pharmacokinetic or toxicological consequences for the human organism. Thus, the present study investigated the influence of co-exposure to RuIII on the subacute toxicity of Ag ions in rats after repeated daily administration for 28 days of low doses by oral gavage. The subacute toxicity was investigated by the evaluation of several biochemical and hematological parameters, evaluation of specific oxidative stress biomarkers from liver and kidney, and histopathological investigation of liver and kidney tissue samples after 28 days of exposure in female rats. In addition, Ag and Ru concentrations were determined by inductively coupled plasma mass spectrometry (ICP-MS) in urine, liver and kidney parenchyma in male rats. The obtained results showed that co-exposure to low doses of RuIII and Ag did not produce any significant biochemical, hematological or histopathological alterations in the treated female rat groups, except for an increased red cell distribution width (RDW) value. A decrease of urinary excretion of Ag and of the Ag concentration in kidneys was observed in the male rat group co-exposed to RuIII and Ag. This is the first invivo study investigating the toxic effect of co-exposure to low doses of Ag and Ru ions, and the obtained results may justify further research on this subject, mainly on the investigation of possible competitive mechanisms.

Details

ISSN :
14482517
Volume :
17
Database :
OpenAIRE
Journal :
Environmental Chemistry
Accession number :
edsair.doi...........efe42dce06f141fffb83611c5b6c89ce
Full Text :
https://doi.org/10.1071/en19249