Double Choroidal Malignant Melanoma in an Eye With Apparent Clinical RegressionDavid apple and milton boniuk, editors

Multicentric melanomas in the same eye are rare, with few cases substantiated by histology and serial sectioning. We report a patient with two documented choroidal malignant melanomas in one eye. The initial tumor spontaneously decreased in size for over 2 years before a second tumor appeared in a noncontiguous location in the same eye. After enucleation, serial sections showed that the two lesions were independent choroidal melanomas. We review the literature regarding multiple, independent intraocular choroidal malignant melanomas. ( Surv Ophthalmol 42 :441–448, 1998.