ChemInform Abstract: Ring-Opening Reaction of 2-Amino-4,5-dihydro-3-furancarbonitriles with Carboxylic Acids under Solvent-Free Conditions

The novel preparation of 2‐cyanobutanamide derivatives starting from 2‐amino‐4,5‐dihydro‐3‐furancarbonitriles is described. Thermal treatment of 4,5‐dihydro‐2‐(4‐morpholinyl, 1‐piperidinyl, and 1‐pyrrolidinyl)‐3‐furancarbonitriles with various carboxylic acids in the absence of solvent caused a ring‐opening reaction to give the corresponding 2‐cyanobutanamide derivatives.