Back to Search
Start Over
An electrochemical aptasensor based on bifunctional Fe3O4@Au nanocomposites for adenosine triphosphate assay
- Source :
- Journal of Solid State Electrochemistry. 25:1073-1081
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- We describe a label-free electrochemical aptasensor for adenosine triphosphate (ATP) assay based on bifunctional Fe3O4@Au nanocomposites. Due to the introduction of Au nanoparticles, the resulting bifunctional Fe3O4@Au nanocomposites can be easily modified with ATP-specific aptamer molecules through Au–S interaction to build the nanoprobe and used to immobilize on a glassy carbon electrode simply with the assistance of a magnet. Once exposed to the target ATP, the current signal obtained at nanoprobe-containing magnetic glassy carbon electrode decreases immediately. The decrease in sensor current is a result of the less methylene blue adsorbed on the aptamer caused by the fact that the ATP-specific aptamer prefers to bind with ATP rather than with methylene blue. The decrease in sensor current can be used for electrochemical determination of ATP, for example, to determine ATP in human serum samples.
- Subjects :
- Nanocomposite
Aptamer
Nanoparticle
Nanoprobe
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
Electrochemistry
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
chemistry.chemical_compound
chemistry
General Materials Science
Electrical and Electronic Engineering
0210 nano-technology
Bifunctional
Adenosine triphosphate
Methylene blue
Subjects
Details
- ISSN :
- 14330768 and 14328488
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Journal of Solid State Electrochemistry
- Accession number :
- edsair.doi...........eed3bdb122ccf3505bb5fae81bce04c1