Back to Search Start Over

Comparison of the predictive power of two models of cortico-cortical connections in primates: the distance rule model and the structural model

Authors :
Gonzalo Aparicio-Rodríguez
Miguel Ángel García-Cabezas
Source :
Cerebral Cortex.
Publication Year :
2023
Publisher :
Oxford University Press (OUP), 2023.

Abstract

Synaptic tract-tracing studies in macaques have provided a wealth of data about cortico-cortical connections that have been used to identify regularities and propose models and theories to explain cortical connectivity. The two most relevant of these models are the distance rule model (DRM) and the structural model (SM). They relate the strength and laminar pattern of cortico-cortical connections to two different factors: Euclidean distance (according to the DRM) and cortical type distance (according to the SM). If both predictive factors were correlated, the DRM and the SM would be compatible, but quite often, two cortical areas of similar cortical type are far apart from each other. In the present article, we have performed a conceptual analysis of the DRM and the SM to obtain predictions from each of the two models about strength and laminar pattern of cortico-cortical connections. We then tested the predictive power of each model with analyses of several cortico-cortical connectivity databases to check which of them provide the most accurate predictions. We conclude that the DRM and the SM capture the decrease in connection strength with increasing Euclidean and cortical type distances, respectively; but, for laminar pattern, type distance is a better predictor than Euclidean distance.

Details

ISSN :
14602199 and 10473211
Database :
OpenAIRE
Journal :
Cerebral Cortex
Accession number :
edsair.doi...........eed3798c24312a9841af0bc9aa8d8df7
Full Text :
https://doi.org/10.1093/cercor/bhad104