Simultaneous confidence intervals for pairwise multiple comparisons in a two-way unbalanced design with unequal variances

In this research, we propose simultaneous confidence intervals for all pairwise multiple comparisons in a two-way unbalanced design with unequal variances, using a parametric bootstrap approach. Simulation results show that Type 1 error of the multiple comparison test is close to the nominal level even for small samples. They also show that the proposed method outperforms Tukey–Kramer procedure when variances are heteroscedastic and group sizes are unequal.