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Multikilogram Synthesis of a Potent Dual Bcl-2/Bcl-xL Antagonist. 1. Manufacture of the Acid Moiety and Development of Some Key Reactions
- Source :
- Organic Process Research & Development. 24:652-669
- Publication Year :
- 2019
- Publisher :
- American Chemical Society (ACS), 2019.
-
Abstract
- Our efforts toward the process development of drug candidate 1 are described in a series of two papers. This manuscript focuses on the synthesis of kilogram quantities of acid precursor 2 to provid...
Details
- ISSN :
- 1520586X and 10836160
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Organic Process Research & Development
- Accession number :
- edsair.doi...........ed4125e9a1becd66e9e190e3d5397143
- Full Text :
- https://doi.org/10.1021/acs.oprd.9b00364