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Sonication-Assisted Synthesis of(E)-2-Methyl-but-2-enyl Nucleoside Phosphonate Prodrugs
- Source :
- ChemistrySelect. 1:3108-3113
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Several hitherto unknown acyclic 2-methyl-but-2-enyl nucleoside phosphonate analogs (ANPs) and their bis-(pivaloyloxymethyl) prodrug forms were prepared by a challenging ultrasonic-assisted olefin cross metathesis and further modifications under microwaves, giving rise to a small library of title compounds. These ANPs were evaluated against a wide spectrum of DNA/RNA viruses. Among them, the most active compound exhibited a micromolar anti-HIV-1 activity with an EC50 of 1.1 µM and an EC90 of 4.2 µM.
Details
- ISSN :
- 23656549
- Volume :
- 1
- Database :
- OpenAIRE
- Journal :
- ChemistrySelect
- Accession number :
- edsair.doi...........ed1c2336a6a29eb16ee482b070ee99ca