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Ultrastructural difractometric and chemical evaluations of calciumpartially stabilized zirconium (Ca-PSZ) implants were performed in an invivo study on animals in order to evaluate its biological behaviour. Thechemical–morphological investigations demonstrated the presence of anosteogenetic activity at the bone–biomaterial interface. Thenew-osteogenesis was preceded by the formation of a loose connective tissuearound the implants. This mesenchymal-type tissue without a capsularorganization, allowing modulation of the mechanical forces to which the implantis subject, could be considered a positive event in the osteogenetic process andnot a sign of future failure of the implant. Finally, microanalyticalinvestigations carried out on non-implanted and implanted Ca-PSZ tools suggestedthat the surface of this ceramic material does not undergo modification once ithas been inserted in the biological environment (12 months).