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3-Substituted 1-methoxypyridinium ions: substituent effects on rates of hydrogen-deuterium exchange
- Source :
- The Journal of Organic Chemistry. 48:2327-2329
- Publication Year :
- 1983
- Publisher :
- American Chemical Society (ACS), 1983.
-
Abstract
- Pyridinium ylides are formed by deprotonation of the 2- and 6-positions of 3-substituted 1-methoxypyridinium ions in heavy water buffer solutions at 75.0/sup 0/C in reactions catalyzed by deuterioxide ion. Dual substituent parameter equations employing inductive and resonance effects correlate rate constants very well. Both 1- and 3-substituents have an additive influence on the reactivity of the 2-position even when reactivity approaches a diffusion-controlled limit. 1 figure, 2 tables.
Details
- ISSN :
- 15206904 and 00223263
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- The Journal of Organic Chemistry
- Accession number :
- edsair.doi...........ec82ba4e3de5abe805863c19aab77295