AHR-3219, a new antianxiety agent

1. 1. AHR-3219 blocked tonic seizures induced by maximal electroshock or pentylenetetrazol in mice in doses comparable to those of diazepam. 2. 2. The drug produced muscle relaxation in mice or cats in doses comparable to or less than those of diazepam, respectively. 3. 3. The antianxiety activity of AHR-3219, as determined in rats by blockade of natural aversion (disinhibition) or of conditioned suppression (conflict behavior), was similar to that seen after diazepam. 4. 4. Lethality studies suggested that AHR-3219 and diazepam were equally toxic after intraperitoneal administration while AHR-3219 was less toxic after oral administration.