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Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms
- Source :
- Digestive and Liver Disease. 46:527-534
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Background The blood brain barrier tightly regulates the passage of molecules into the brain and becomes leaky following obstructive cholestasis. The aim of this study was to determine if increased serum bile acids observed during cholestasis permeabilize the blood brain barrier.
- Subjects :
- medicine.medical_specialty
Hepatology
Tight junction
business.industry
Deoxycholic acid
Gastroenterology
Occludin
medicine.disease
Blood–brain barrier
chemistry.chemical_compound
Endocrinology
medicine.anatomical_structure
Biochemistry
chemistry
Cholestasis
Internal medicine
Chenodeoxycholic acid
medicine
Phosphorylation
business
Ligation
Subjects
Details
- ISSN :
- 15908658
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Digestive and Liver Disease
- Accession number :
- edsair.doi...........ec4d2819c9c63d66d8180ae5e40a56fd