Association of total cholesterol/apoB100 with lipid and protein oxidation products in stable angina patients treated with statins

Oxidative modification of lipids contained in lipoproteins may contribute to initiation of local inflammation in the vascular endothelium and ultimately to the atherosclerotic plaque formation. Therefore, in patients with high cardiovascular risk in primary as well as in secondary prevention, it is recommended that the serum low-density lipoprotein (LDL) cholesterol be reduced. However, the management of patients with LDL level at goal is still a matter of debate. Various parameters have been proposed for predicting increased cardiovascular risk. It was found that among known indicators of lipid metabolism deregulation the ratio of total cholesterol/apoB100 associates with the severity of coronary arteriosclerosis in population of individuals with LDL levels 100 mg/dL). See commentary by Grabowski http://dx.doi.org/10.1002/ejlt.201200295