Total Syntheses of CP-225,917 and CP-263,114: Creation of a Matrix Structure By Sequential Aldol Condensation and Intramolecular Heck Ring Closure

Authors :: Ohyun Kwon
Dongfang Meng
Derin C. D'Amico
Dai-Shi Su
Wei Deng
Samuel J. Danishefsky
Source :: Angewandte Chemie International Edition. 37:1877-1880
Publication Year :: 1998
Publisher :: Wiley, 1998.
Abstract: Important progress towards the total syntheses of the title compounds, potent inhibitors of squalene synthase and farnesyl transferase, has been accomplished by the construction of the highly functionalized compound 1.

Subjects :: Stereochemistry
organic chemicals
General Chemistry
Ring (chemistry)
environment and public health
Catalysis
Matrix (chemical analysis)
Squalene
chemistry.chemical_compound
Aldol reaction
chemistry
Intramolecular force
lipids (amino acids, peptides, and proteins)
Aldol condensation
Farnesyl Transferase

ISSN :: 15213773 and 14337851
Volume :: 37
Database :: OpenAIRE
Journal :: Angewandte Chemie International Edition
Accession number :: edsair.doi...........ebdd411dfdd005a1d2104fdfb3567941
Full Text :: https://doi.org/10.1002/(sici)1521-3773(19980803)37:13/14<1877::aid-anie1877>3.0.co;2-2

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