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Efficient Synthesis of Novel Oxime Analogues of the Hormone 1α, 25-Dihydroxyvitamin D3
- Source :
- Journal of Chemical Research. 39:368-372
- Publication Year :
- 2015
- Publisher :
- SAGE Publications, 2015.
-
Abstract
- Calcitriol analogues which contained an oxime in the side chain were synthesised in five steps from an intermediate 22-nor Ketone. The key intermediate enones were synthesised by the Wittig–Horner olefination and Wittig olefination respectively. Reduction, oximation, photoisomerisation and deprotection gave the target compounds with the oxime at C-24.
Details
- ISSN :
- 20476507 and 17475198
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Journal of Chemical Research
- Accession number :
- edsair.doi...........eb89cfae3f0bba30fed9d30333733e00