Synthesis of Hybrid Fe3O4–Silica–M(Zn, Cu, Ni) Submicrospheres and its Application for Adsorption on Bovine Hemoglobin

Magnetic metal silica submicrospheres were produced from silica coated on magnetic nanoparticles using well controlled hydrothermalled method and were characterized by TEM, XRD, FTIR, XPS. The well-designed mesoporous magnetic metal silciate had a large specific area, high magnetization. Firstly, SiO2-coated maghemite (Fe3O4@SiO2 composites) were synthesized by an sol-gel method, in which the iron ferrous chloride as well as TEOS acted as the precursor for maghemite and SiO2, respectively. The Fe3O4@SiO2 composites revealed a core-shell structure, Then, Fe3O4@SiO2/X3Si2O5(OH)4(X = Ni, Cu, Zn) was obtained by hydrothermalled with metal chloride. The resulting composites show not only a magnetic response to an externally applied magnetic field, but also can be a good adsorbent for bovine hemoglobin in the ambient temperature.