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Genetic variants in the FAM3C gene are associated with lipid traits in Chinese children
- Source :
- Pediatric Research. 89:673-678
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Background Previous studies have related FAM3C gene with childhood bone health, and the regulation of lipid metabolism in hepatocytes. The present case-control study aimed to analyze the association of FAM3C genetic variants with overweight/obesity and lipid traits among Chinese children. Methods Two genetic variants (rs7776725 and rs7793554) within the FAM3C gene were genotyped in 3305 Chinese children aged 6-18 years. Results In the whole study population, the T-allele of rs7776725 and A-allele of rs7793554 within the FAM3C gene were associated with 40.2% (95% CI: 11.6-76.1%; P = 0.004) and 29.1% (6.9-56.0%; P = 0.008) increased risk of dyslipidemia, higher triglyceride (P = 0.014 and P = 0.001) and lower HDL-C (P = 0.015 and P = 0.003). In addition, we found that rs7776725 interacted with sex on dyslipidemia (Pfor interaction = 0.004), and sex-stratified analyses showed that it was significantly associated with dyslipidemia only in girls (P = 8.78 × 10-5). The variant also showed nominally significant interactions with sex on total cholesterol and LDL-C (Pfor interaction = 0.012 and 0.008). Conclusion We found that FAM3C genetic variants were associated with dyslipidemia and lipid traits among Chinese children. In addition, we found significant gene-by-sex interactions. Our findings provided evidence supporting the role of FAM3C gene in regulating lipid metabolism in humans. Impact FAM3C genetic variants were associated with dyslipidemia and lipid traits among Chinese children. In addition, we found significant gene-by-sex interactions.FAM3C/rs7776725 was associated with dyslipidemia and lipid traits only in girls.Our findings provided evidence supporting the role of FAM3C gene in regulating lipid metabolism in humans.
- Subjects :
- medicine.medical_specialty
Triglyceride
Genetic variants
Lipid metabolism
Overweight
Biology
medicine.disease
Obesity
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
chemistry
030225 pediatrics
Internal medicine
Pediatrics, Perinatology and Child Health
medicine
Population study
medicine.symptom
030217 neurology & neurosurgery
FAM3C Gene
Dyslipidemia
Subjects
Details
- ISSN :
- 15300447 and 00313998
- Volume :
- 89
- Database :
- OpenAIRE
- Journal :
- Pediatric Research
- Accession number :
- edsair.doi...........eb70818ba4fbdb3ad8080943cea434ea