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Glucokinase Activators Based on N-Aryl-N′-Pyridin-2-Ylurea Derivatives
- Source :
- Pharmaceutical Chemistry Journal. 52:209-212
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- A series of previously undescribed N-aryl-N′-pyridin-2-ylureas were prepared via the reaction of 2-aminopyridines with benzoyl azides and tested in vitro as activators of glucokinase. Statistically significant reductions of glucose levels as compared with controls were demonstrated for several compounds.
Details
- ISSN :
- 15739031 and 0091150X
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Pharmaceutical Chemistry Journal
- Accession number :
- edsair.doi...........eb3ef3bdd818426e55d0f6aae95e6331
- Full Text :
- https://doi.org/10.1007/s11094-018-1792-7