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Mupirocin Treatment of Nasal Staphylococcal Colonization
- Source :
- Archives of Internal Medicine. 152:353
- Publication Year :
- 1992
- Publisher :
- American Medical Association (AMA), 1992.
-
Abstract
- The effectiveness and safety of mupirocin calcium ointment applied to the anterior part of the nares for 5 days in the eradication of nasal carriage ofStaphylococcus aureuswas investigated in a placebo-controlled, double-blind study. Subjects were healthy medical center staff who had two positive cultures of the anterior nares forS aureus. Antimicrobial susceptibility, phage typing, and restriction endonuclease analysis of plasmid DNA were used to monitor the identity of relapsing and persisting strains. Mupirocin eliminated 74% ofS aureusat early follow-up and 91% of original strains. At 4 weeks, 78% of the original strains were eradicated, whereas all of the placebo group remained colonized. Recolonization with mupirocin-resistant strains occurred in six patients, but these were of different phage and plasmid types from the original isolates. None of the subjects had serious adverse effects. Applied intranasally for 5 days, a calcium preparation of mupirocin in a paraffin base is effective in eliminatingS aureusnasal carriage and is well tolerated. (Arch Intern Med.1992;152:353-356)
- Subjects :
- Mupirocin Calcium
Micrococcaceae
biology
business.industry
medicine.drug_class
Antibiotics
Mupirocin
biology.organism_classification
medicine.disease_cause
Microbiology
Anterior nares
chemistry.chemical_compound
medicine.anatomical_structure
chemistry
Internal Medicine
Medicine
business
Staphylococcus
Nose
Phage typing
Subjects
Details
- ISSN :
- 00039926
- Volume :
- 152
- Database :
- OpenAIRE
- Journal :
- Archives of Internal Medicine
- Accession number :
- edsair.doi...........eae301daa6f25eda7c7e39e92aa9c65f
- Full Text :
- https://doi.org/10.1001/archinte.1992.00400140099022