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Mupirocin Treatment of Nasal Staphylococcal Colonization

Authors :
Francisco Briones
Brian E. Scully
Jian-Wei Gu
Harold C. Neu
Source :
Archives of Internal Medicine. 152:353
Publication Year :
1992
Publisher :
American Medical Association (AMA), 1992.

Abstract

The effectiveness and safety of mupirocin calcium ointment applied to the anterior part of the nares for 5 days in the eradication of nasal carriage ofStaphylococcus aureuswas investigated in a placebo-controlled, double-blind study. Subjects were healthy medical center staff who had two positive cultures of the anterior nares forS aureus. Antimicrobial susceptibility, phage typing, and restriction endonuclease analysis of plasmid DNA were used to monitor the identity of relapsing and persisting strains. Mupirocin eliminated 74% ofS aureusat early follow-up and 91% of original strains. At 4 weeks, 78% of the original strains were eradicated, whereas all of the placebo group remained colonized. Recolonization with mupirocin-resistant strains occurred in six patients, but these were of different phage and plasmid types from the original isolates. None of the subjects had serious adverse effects. Applied intranasally for 5 days, a calcium preparation of mupirocin in a paraffin base is effective in eliminatingS aureusnasal carriage and is well tolerated. (Arch Intern Med.1992;152:353-356)

Details

ISSN :
00039926
Volume :
152
Database :
OpenAIRE
Journal :
Archives of Internal Medicine
Accession number :
edsair.doi...........eae301daa6f25eda7c7e39e92aa9c65f
Full Text :
https://doi.org/10.1001/archinte.1992.00400140099022