USP25 mice model for IgG4-RD

IgG4-related disease has been manifested with fibrosis, inflammation and deregulated metabolism clinical symptoms. In this study, we have investigated the molecular mechanism of aforementioned clinical symptoms with PBMC from IgG4-RD patients, IgG4 cells lines and USP25 KO mice. By using RNA-seq, we have identified that USP25 controls the symptoms via several pathways as the central hub.