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Incorporating Pharmacokinetic/Pharmacodynamic Modeling in Drug DevelopmentāAre We Ready?
- Source :
- Drug Information Journal. 26:119-124
- Publication Year :
- 1992
- Publisher :
- Springer Science and Business Media LLC, 1992.
-
Abstract
- There is a growing awareness that simply saying that a drug is effective (ie, the p value is less than 0.05) is not adequate information for the optimal treatment of patients. It is increasingly appreciated that drugs act differently in different populations, for example the elderly, and at different doses or serum concentrations. These relationships should be defined to optimize use of drugs in different populations. Techniques are discussed that allow investigators to better describe the pharmacokinetic and pharmacodynamics response for individual patients. The term population pharmacokinetic/pharmacodynamic analysis (population PK/PD) has been applied to a collection of these techniques. The role of population PK/PD in the drug development process remains to be defined, but should be expanded.
- Subjects :
- Drug
media_common.quotation_subject
Population
Pharmacology (nursing)
Pharmacology
Bioinformatics
030226 pharmacology & pharmacy
01 natural sciences
010104 statistics & probability
03 medical and health sciences
0302 clinical medicine
Pharmacokinetics
Drug Guides
Medicine
Pharmacology (medical)
0101 mathematics
education
media_common
education.field_of_study
business.industry
Pharmacokinetic pharmacodynamic
Optimal treatment
Public Health, Environmental and Occupational Health
NONMEM
Drug development
Pharmacodynamics
business
Subjects
Details
- ISSN :
- 00928615
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Drug Information Journal
- Accession number :
- edsair.doi...........ea0972dde49f7339e3be278f853ceaf0