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Infection par le virus de l’immunodéficience humaine
- Source :
- médecine/sciences. 31:1092-1101
- Publication Year :
- 2015
- Publisher :
- EDP Sciences, 2015.
-
Abstract
- The gut associated lymphoid tissue (GALT) is the site of numerous immunological disturbances during HIV-1 infection. It constitutes the largest reservoir for HIV, not or very poorly susceptible to antiretroviral therapy (ART), making it a major obstacle to HIV cure. Moreover, the GALT is involved in systemic immune activation in HIV-infected individuals: intestinal damage due to viral replication and severe CD4(+) T cell depletion in the GALT leads to microbial translocation, a key driver of immune activation, and in turn, disease progression. In this review, we describe the role of the GALT in HIV infection and we discuss therapeutic options to decrease the intestinal viral reservoir and to preserve immune function in the gut of HIV-infected people. Achieving these goals is necessary for a long-term infection control after the interruption of ART.
- Subjects :
- business.industry
Gut-associated lymphoid tissue
Human immunodeficiency virus (HIV)
General Medicine
medicine.disease_cause
Antiretroviral therapy
General Biochemistry, Genetics and Molecular Biology
medicine.anatomical_structure
Lymphatic system
Immune system
Viral replication
Immunology
medicine
Infection control
business
Microbial translocation
Subjects
Details
- ISSN :
- 19585381 and 07670974
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- médecine/sciences
- Accession number :
- edsair.doi...........e9eaed4ff22a439ba76a454b81ee00be