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Scaffolds for epithelial and hair follicle regeneration
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- In repair of acute or chronic wounds, timely closure of open wounds with continuous epithelial layer would be essential for reassurance of the barrier functions of healed skin. Meanwhile, regeneration of those accessory appendages like hair follicles in the healed wounds would be a vital step toward the restoration of the full physiologic functions of skin. To facilitate the process of abovementioned scenarios, coverage of wounds with skin grafts would be an appealing strategy. In the endeavor of creating tissue-engineered skin substitutes including epithelial sheet and those with hair follicles, it becomes recognizably important to formulate a cell-friendly microenvironment favoring the desired cell phenotype. Considering dimensional and morphological similarity of electrospun fibrous matrices to native extracellular matrix , it is highly beneficial to define the cell-growing environment with such fibers. This chapter not only provides the fundamentals on skin epithelial structures and hair follicles but also summarizes the up-to-date tactics in using electrospun matrices for engineering epithelial layers and hair follicle-like structures.
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi...........e7e1a1baf070a00bd5a576a436b49f5e
- Full Text :
- https://doi.org/10.1016/b978-0-08-102561-1.00009-9