Effect of platelet-rich fibrin on the donor site of Split thickness skin graft in burn patients

Background: Patients with massive burn areas have now a greater chance of survival thanks to improved modalities of new treatments. In some patients it is necessary to harvest multiple skin grafts from the same donor site which is restricted by the quality of the skin and the time required to recover; this procedure can take a long time and may increase the danger of bacterial contamination, resulting in increased morbidity and mortality in these individuals. Platelet-rich fibrin is one of the newest autologous growth factors utilized for wound management. PRF application can significantly improve the wound's condition by supplying growth factors to the wound environment, which aid in the epithelialization process's acceleration, resulting in cost-effective wound management. This will allow multiple harvesting from the same donor site, reducing costs, hospitalization time, scars, and co-morbidities. Aim of the Work: To assess the role of PRF in accelerating wound healing in the donor site following skin grafting in burn patients.patients and Methods: This prospective, controlled, clinical trial study was done from April 2020 to April 2021 included 20 patients at the burn unit of El Demerdash Hospital Ain Shams University.Results: The current study showed that healing days in donor sites injected with PRF were lower than those of controlled areas with statistical significance. Mean epidermal thickness was lower in the control area than PRF injected areas with statistical significance.Conclusion: PRF can significantly decrease the time of donor wound healing compared to that of conventional treatment.