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Development of Chronic Airway Obstruction in Patients With Eosinophilic Bronchitis
- Source :
- Chest. 125:1998-2004
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- Study objectives Eosinophilic bronchitis (EB) presents as a chronic cough and sputum eosinophilia without airflow limitation or bronchial hyperreactivity. Its long-term clinical course remains unknown. This study evaluated how frequently EB recurs and whether it develops chronic airway obstruction. Design This study was a prospective analysis. Methods Cough severity, FEV 1 , provocative concentration of methacholine causing a 20% fall in FEV 1 , and sputum eosinophil percentages were serially measured in 36 subjects for up to 48 months. All subjects inhaled corticosteroids until cough subsided. Results Five of the twenty four follow-up subjects (21%) had a recurrent episode of EB 4 to 6 months after disappearance of the first episode of EB (recurrent eosinophilic bronchitis). Progressive FEV 1 reduction > 20% was observed in three of the subjects, including a subject with asthma developing at the ninth month. Nineteen subjects had no recurrence of cough (nonrecurrent eosinophilic bronchitis) and no progressive FEV 1 reduction > 20%. However, sputum eosinophilia recurred between 4 months and 24 months in 10 subjects. Mean values of FEV 1 at the ninth and 12th months of the study were significantly lower in the recurrent eosinophilic bronchitis group than in the nonrecurrent eosinophilic bronchitis group (p Conclusion These results suggest that repeated episode of EB is associated with the development of chronic airflow obstruction, including asthma.
- Subjects :
- Pulmonary and Respiratory Medicine
First episode
medicine.medical_specialty
Eosinophilic bronchitis
business.industry
Respiratory disease
respiratory system
Critical Care and Intensive Care Medicine
medicine.disease
Gastroenterology
respiratory tract diseases
Chronic cough
Internal medicine
Anesthesia
medicine
Sputum
Bronchitis
Methacholine
medicine.symptom
Cardiology and Cardiovascular Medicine
business
medicine.drug
Asthma
Subjects
Details
- ISSN :
- 00123692
- Volume :
- 125
- Database :
- OpenAIRE
- Journal :
- Chest
- Accession number :
- edsair.doi...........e7ae6635a77697a4252133f46b52f777