Amoxycillin-Clavulanic Acid-Related Tooth Discoloration in Children

To the Editor. The voluntary communication of isolated adverse drug reactions (ADRs) is the most effective means for the postmarketing identification of rare, serious adverse reactions. These communications can be made to Drug Surveillance Services or to medical and scientific journals. The publication of case reports is an important primary source of information on ADRs and contributes to the improvement of drug safety.1 We present 3 cases of dental discoloration in children related to the administration of amoxicillin-clavulanic acid. No similar cases have been published in either clinical trials or as isolated cases. Case 1 was a 6-year-old girl with a history of allergic rhinitis and asthma subjected to chronic treatment with budesonide …