e0246 Therapeutic effect of a dual-chamber pacemaker with the optimised program-control mode on long-QT syndrome

Objective To explore the optimised program-control mode of a dual-chamber pacemaker combined with β-blocker to treat congenital long QT syndrome (LQTS). Methods 12 LQTS patients in our hospital that still have symptoms despite use of regular drug therapies or that can not endure the therapies were implanted with DDD cardiac pacemaker. The QT/QTc intervals of those patients were measured at different pacing rates respectively. Their cardiac pacemakers were all programmed to selectively turn on and turn off some related functions at the pacing rate of 80 beats/min. The dosage of β-blockers was adjusted according to the patients’ PR intervals and blood pressures. The MACE and the cardiac function of the patients were recorded after operation. Results The measured QT/QTc interval decreased with the pacing rate increasing. The pacing rate of 80 beats/min can make QT/QTc interval basically normal. The MACE of the patients were statistically declined (p=0.003) and no negative effect on cardiac function was found during the follow-up. Conclusion The optimised program-control mode of a dual-chamber pacemaker combined with β-blocker to treat congenital LQTS are: to pace at the rate of 80 beats/min and program to turn off lag, sleep, automatic preventing PMT and automatic threshold-capture feature and turn on the PVC, rate adaptation and atrioventricular node priority function.