Characterization of the Metabolism, Distribution and Toxicity of 2,6-di-t-Butyl-4-Nitrophenol for Purposes of Health Hazard Assessment

In 1992, the Navy Environmental Health Center, Norfolk, VA was made aware of the concern about the discoloration (yellowing) of interiors (e.g. bulkheads and bedding) and the possible exposure of navy personnel aboard submarines, to an - unknown substance. The agent was identified as 2,6-di-tert-butyl-4-nitrophenol (DBNP). The yellowing process appeared to arise from the reaction of 2,6-di-tert-butylphenol (DBP), an antioxidant additive used in engine lubricant, with NO2 in the submarine atmosphere. A research program was initiated for health hazard assessment of DBNP. - This technical report summarizes the results of our research program and the information available in the literature.