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Design and rationale of haemodynamic guidance with CardioMEMS in patients with a left ventricular assist device: the HEMO-VAD pilot study

Authors :
Alina A. Constantinescu
Nicolas M. Van Mieghem
Mattie J. Lenzen
Kadir Caliskan
Corstiaan A. den Uil
Philip B. Adamson
Ozcan Birim
Jesse F. Veenis
Eric Boersma
Jasper J. Brugts
Felix Zijlstra
Olivier C. Manintveld
Jos A. Bekkers
William T. Abraham
Source :
ESC Heart Failure. 6:194-201
Publication Year :
2019
Publisher :
Wiley, 2019.

Abstract

AimsWe aim to study the feasibility and clinical value of pulmonary artery pressure monitoring with the CardioMEMS™device in order to optimize and guide treatment in patients with a HeartMate3left ventricular assist device (LVAD).Methods and resultsIn this single-centre, prospective pilot study, we will include10consecutive patients with New YorkHeart Association Class IIIb or IV with Interagency Registry for Mechanically Assisted Circulatory Support Classes2–5scheduledfor implantation of a HeartMate3LVAD. Prior to LVAD implantation, patients will receive a CardioMEMS sensor, for dailypulmonary pressure readings. The haemodynamic information provided by the CardioMEMS will be used to improvehaemodynamic status prior to LVAD surgery and optimize the timing of LVAD implantation. Post-LVAD implantation, thehaemodynamic changes will be assessed for additive value in detecting potential complications in an earlier stage (bleedingand tamponade). During the outpatient clinic phase, we will assess whether the haemodynamic feedback can optimize pumpsettings, detect potential complications, and further tailor the clinical management of these patients.ConclusionsThe HEMO-VAD study is thefirst prospective pilot study to explore the safety and feasibility of usingCardioMEMS for optimization of LVAD therapy with additional (remote) haemodynamic information.

Details

ISSN :
20555822
Volume :
6
Database :
OpenAIRE
Journal :
ESC Heart Failure
Accession number :
edsair.doi...........e5fafb8db2bde47afc37d83cb8a06119
Full Text :
https://doi.org/10.1002/ehf2.12392