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Reaction of methyl 3-phenyl-3-chloro-2-oxopropionate with thiosemicarbazones
- Source :
- Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 40:1262-1266
- Publication Year :
- 1991
- Publisher :
- Springer Science and Business Media LLC, 1991.
-
Abstract
- The reaction of methyl 3-phenyl-3-chloro-2-oxopropionate with thiosemicarbazones proceeds via the intermediate formation of methyl [S-(1′-alkylideneisothiosemicarbazidyl)]-3-phenyl-2-oxopropionate hydrochlorides, which then cyclize to novel 4-methoxycarbonyl-5-phenyl-2-substituted thiazoles. Hydrolysis of the intermediate products and the thiazoles obtained therefrom with simultaneous distillation of the carbonyl compound affords 2-hydrazino-4-methoxy-carbonyl-5-phenylthiazole.
Details
- ISSN :
- 15739171 and 05685230
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Bulletin of the Academy of Sciences of the USSR Division of Chemical Science
- Accession number :
- edsair.doi...........e5da086917e981e79402b78dc561d0cb