Magnetic Graphene Solid-Phase Extraction for the Determination of 47 Kinds of Non-steroidal Anti-inflammatory Drug Residues in Animal Food with Liquid Chromatography Tandem Mass Spectrometry

Based on magnetic graphene (Fe3O4-G), a liquid chromatography with tandem mass spectrometric detection (LC-MS/MS) method coupled with magnetic solid-phase extraction was developed for the simultaneous detection of 47 kinds of nonsteroidal anti-inflammatory drug (NSAID) residues in meat of swine, chicken, and bovine. The samples were extracted with acetonitrile-phosphate, then the extracts were purified by dispersed solid-phase extraction based on magnetic graphene (Fe3O4-G). The linearity range is 0.1–50 μg L−1. Limits of detection were between 0.1 μg kg−1 and 0.5 μg kg−1, and limits of quantification were between 0.5 μg kg−1 and 1.0 μg kg−1. The average recoveries were 72.4–97.1% at spiking levels. The inter-day RSDs varied from 5.3 to 12.6%. Due to the advantages of easy collection of magnetic solid-phase extraction materials, the method was more rapid and efficient for the enrichment and separation without filling columns. The sensitivity, precision, and accuracy method was suitable for simultaneous detection of multi-component residues of nonsteroidal anti-inflammatory drugs.