Retrospective Analysis Of Patients And Treatment Characteristics: Istanbul Cyberknife Coalition Data

Background: To evaluate the patient and treatment characteristics of four radiotherapy centers with robotic systems (CyberKnife) in Istanbul. Materials and Methods: Five hundred and ninety-three patients treated with CyberKnife (CK) system during 2010 were included in this study. Data regarding their diagnosis, radiosurgery (SRS) indications, total treatment doses, and number of fractions were analyzed. Results: Patient numbers from each center were as follows: Acibadem University Maslak Hospital (186), Kartal Egitim ve Arastirma Hospital (161), Anadolu Saglik Merkezi (145), and Istanbul University Istanbul Medical Faculty Radiation Oncology Department (101). Median age of the patients (355 males (59.9%), 238 females (40.1%)) was 55 years (range: 8-87). Intracranial tumors (77.2%) were biggest group, according to location of the disease. Distribution in terms of diagnosis were as follows: metastasis to brain (36.6%), spinal and paraspinal tumors (8.8%), primary lung tumors (7.4%), head-neck tumors (6.1%), glial tumors (5.9%), meningioma (5.4%), other brain malignancies (4.6%), lung metastasis (4.2%), acoustic neuroma (3.9%), other intracranial lesions (3.9%), intra-abdominal malignacy and extracranial metastases (2.9%), liver lesions (2.4%), pituitary adenoma (2.2%), adrenal metastases (1.5%), uveal melanoma (1.3%), prostate cancer (1.2%), pancreatic cancer (0.5%), extracranial schwannoma (0.5%), and unclassified other tumors (0.8%). CK was used as primary treatment in 348 patients, for reirradiation in 209 patients, for planned boost in 26 patients, and in 10 patients for recurrence in previous field edge. Total median dose of whole group was 2100 cGy (800-7500 cGy), median dose per fraction was 800 cGy (200-3750), and median total fraction number was three (1-10).