Synthesis, binding affinity and antioxidant activity of new 1,4-dihydropyridines

The synthesis and in vitro pharmacology of a series of triaryl-1,4-dihydropyridines were investigated. Molecules containing a nitro group on the phenyl ring had a higher affinity for specific [ 3 H](+)-PN 200-110 binding sites. All the compounds possessed a radical scavenging effect and an antiperoxidant activity. These properties were more marked for molecules with 2-pyridinyl and 2-thienyl substituents. The synthesis of new triaryl-1,4-dihydropyridines with both a higher binding affinity and antioxidant activity might be effective in cerebral ischemic disease treatment.