An efficient route to chiral, non-racemic 3-alkyl-3-arylpyrrolidines. Improved stereoselectivity in alkylation of bicyclic lactams and the effect of leaving groups

Authors :: Kozo Oda
Albert I. Meyers
Source :: Tetrahedron Letters. 41:8193-8197
Publication Year :: 2000
Publisher :: Elsevier BV, 2000.
Abstract: Chiral 3-alkyl-3-arylpyrrolidines were prepared from the substituted bicyclic lactams. Stereoselectivity in the alkylation of bicyclic lactams was improved by using an alkyl triflate or tosylate as the electrophile.

Subjects :: chemistry.chemical_classification
Bicyclic molecule
Organic Chemistry
biochemical phenomena, metabolism, and nutrition
Alkylation
Biochemistry
Medicinal chemistry
chemistry
Drug Discovery
Electrophile
polycyclic compounds
lipids (amino acids, peptides, and proteins)
Stereoselectivity
Trifluoromethanesulfonate
Alkyl

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