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Phospholipase A2 inhibitors from marine algae

Authors :
Robert S. Jacobs
Alejandro M. S. Mayer
William Fenical
M. S. de Carvalho
Valerie J. Paul
James N. Norris
Source :
Fourteenth International Seaweed Symposium ISBN: 9789401048828
Publication Year :
1993
Publisher :
Springer Netherlands, 1993.

Abstract

Twelve out of twenty-nine compounds isolated from benthic marine algae from the phyla Chlorophyta, Phaeophyta and Rhodophyta have been found to be potent inhibitors of bee venom derived phospholipase A2 (PLA2) (> 50%) in the μM range. The compounds investigated were from: Bryopsis pennata, Rhipocephalus phoenix, Caulerpa prolifera, C. racemosa, C. bikinensis, Cymopolia barbata, Laurencia cf. palisada, Laurencia sp., Ochtodes crockeri, Liagora farinosa, Sphaerococcus coronipifolius, Phacelocarpus labillardieri, Dictyota sp., Bifurcaria galapagensis, Stypopodium zonale, Dictyopteris undulata, Stoechospermum marginatum, Dictyopteris divaricata, Dilophus fasciola and Dilophus sp. This is the first report of bee venom PLA2 inhibition in vitro by pure compounds isolated from marine algae.

Details

ISBN :
978-94-010-4882-8
ISBNs :
9789401048828
Database :
OpenAIRE
Journal :
Fourteenth International Seaweed Symposium ISBN: 9789401048828
Accession number :
edsair.doi...........e479ca5d31151875759edf1e7d5455ed
Full Text :
https://doi.org/10.1007/978-94-011-1998-6_69