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Autocrine Secretion and Carcinogenesis
- Source :
- Anticarcinogenesis and Radiation Protection 2 ISBN: 9781461367185
- Publication Year :
- 1991
- Publisher :
- Springer US, 1991.
-
Abstract
- Continuous secretion of a variety of growth factors, hormones and other regulatory elements is a common characteristic of tumor cells. The inappropriate control of the expression of some tissue-specific proteins and the ectopic synthesis of biologically active molecules such as various autocrine mitogenes, transforming growth factors, and differentiation-inhibiting or differentiation-inducing factors, result from a pleiotropic effect of oncogene activities in malignant cells that derepress and/or keep active a number of genes, which are normally silent in differentiated cells (1). Available literature on growth factors and hormones secreted by both normal and malignant cells is so vast that inevitably a reduced number of contributions will be referenced in this short overview.
Details
- ISBN :
- 978-1-4613-6718-5
- ISBNs :
- 9781461367185
- Database :
- OpenAIRE
- Journal :
- Anticarcinogenesis and Radiation Protection 2 ISBN: 9781461367185
- Accession number :
- edsair.doi...........e4798648af6c1bd96ed861047ccb0776