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Reductive Amination of Sterically Hindered Arylaminoketones Using a Modified Leuckart Reaction
- Source :
- Pharmaceutical Chemistry Journal. 52:545-549
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- The Leuckart reaction offers a fast and convenient method for synthesizing various formamides, amines, and large numbers of biologically active compounds and pharmaceuticals. New 5-(N-piperidino)-1-arylpentan-1-ones (1a-f) and 5-(N-piperidino)-1-aryl-1-aminopentanes (2a-f) were synthesized. The properties of starting aminoketones 1a-f for synthesizing arylaminoketones 2a-f under Leuckart reaction conditions and their thermal stability over a broad temperature interval were studied. The optimal conditions for the key synthetic step, i.e., the Leuckart reaction, were determined experimentally.
Details
- ISSN :
- 15739031 and 0091150X
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Pharmaceutical Chemistry Journal
- Accession number :
- edsair.doi...........e42939bb2d41da06a3938e99e94f850d