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The Prevalence of Methicillin-Resistant Staphylococcus aureus Colonization in Patients with Complicated Skin and Skin Structure Infections after Treatment with Linezolid or Vancomycin
- Source :
- Advances in Infectious Diseases. :186-193
- Publication Year :
- 2014
- Publisher :
- Scientific Research Publishing, Inc., 2014.
-
Abstract
- Background: Complicated skin and skin structure infections (cSSSIs) due to Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA), are associated with significant morbidity. Re-ducing MRSA carriage has been a focus of infection control interventions. The prevalence of MRSA colonization after successful treatment of a MRSA cSSSI is unknown. Methods: Secondary analysis of a randomized controlled trial comparing linezolid and vancomycin for the treatment of MRSA cSSSI. Adult patients that had a colonization culture, confirmed MRSA cSSSI, received at least one dose of study treatment, and had an outcome recorded at end of study. Patient, clinical characteristics and prevalence of colonization were compared by treatment regimens. A multivariate regression model identified predictors of MRSA colonization at EOS. Results: There were 456 patients evaluated. The prevalence of MRSA colonization was higher for vancomycin treated patients compared to linezolid treated patients at end of treatment (EOT) (28% vs. 5%, p < 0.001) and EOS (34% vs. 22%, p < 0.01). Independent predictors of colonization at EOS after treatment for a MRSA cSSSI included diagnosis, primarily driven by abscess, black race, treatment with vancomycin, MRSA mixed infection and male gender. Conclusion: Patients treated with linezolid for a cSSSI had less MRSA colonization at EOT and EOS compared to those treated with vancomycin. Multiple independent predictors of MRSA colonization were identified. Additional studies evaluating the relationship of MRSA colonization after treatment of cSSSI are needed.
- Subjects :
- medicine.medical_specialty
business.industry
biochemical phenomena, metabolism, and nutrition
bacterial infections and mycoses
medicine.disease
medicine.disease_cause
Methicillin-resistant Staphylococcus aureus
Surgery
chemistry.chemical_compound
General Energy
Carriage
chemistry
Staphylococcus aureus
Internal medicine
Linezolid
medicine
Vancomycin
Infection control
Colonization
Abscess
business
medicine.drug
Subjects
Details
- ISSN :
- 21642656 and 21642648
- Database :
- OpenAIRE
- Journal :
- Advances in Infectious Diseases
- Accession number :
- edsair.doi...........e3ffde915a43ae2dd75379356227390b