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BIOGENESE VON ÖSTRATETRAENOL BEIM MENSCHEN
- Source :
- Acta Endocrinologica. 42:129-134
- Publication Year :
- 1963
- Publisher :
- Oxford University Press (OUP), 1963.
-
Abstract
- Incubation of androsta-4,16-dien-3-one with 10 000 × g supernatant of human placenta tissue resulted in the formation of a phenolic metabolite. This was isolated and subsequently identified as oestratetraen-3-ol by its melting point, paper chromatography, and the absorption curves of the sulphuric acid water reaction and the Kober reaction. The conversion of androsta-4,16-dien-3-one to oestratetraen-3-ol was approximately 25%, whereas under similar conditions testosterone was aromatised to oestradiol-17β (and oestrone) in a 30% yield. The significance of these results is discussed with regard to the conversion of testosterone to 16,17-epioestriol.
Details
- ISSN :
- 1479683X and 08044643
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Acta Endocrinologica
- Accession number :
- edsair.doi...........e3b971c70d74f31637596dff868b0e70