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[Untitled]
- Source :
- Journal of Neurocytology. 29:425-437
- Publication Year :
- 2000
- Publisher :
- Springer Science and Business Media LLC, 2000.
-
Abstract
- Several in vitro and in vivo studies have shown that estrogen has neuroprotective properties. The neuroprotective effects of estrogen are probably exerted through several mechanisms. It is established that estrogen can provide neuroprotection by actions that are independent of estrogen receptor activation. In addition, in several experimental models, activation of estrogen receptors appears to be indispensable for neuroprotection. This review focuses on neuroprotection mediated by estrogen receptors. The interaction of estrogen with growth factor receptor signaling to induce neuroprotection is discussed. Evidence is presented that estrogen receptors and insulin-like growth factor-I receptors interact in the promotion of neuronal survival and neuroprotection.
- Subjects :
- Histology
medicine.drug_class
General Neuroscience
medicine.medical_treatment
Estrogen receptor
Cell Biology
Pharmacology
Biology
Neuroprotection
Insulin-like growth factor
Growth factor receptor
Estrogen
medicine
Growth factor receptor inhibitor
Anatomy
Receptor
hormones, hormone substitutes, and hormone antagonists
Estrogen receptor beta
Subjects
Details
- ISSN :
- 03004864
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Journal of Neurocytology
- Accession number :
- edsair.doi...........e38d6cf724bf72e6134ee8cd7b19f54a