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Homo-N-nucleosides: Incorporation into oligonucleotides and antiviral activity
- Source :
- Bioorganic & Medicinal Chemistry Letters. 6:1465-1468
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- Homo-N-nucleosides can be efficiently synthesized from 2-deoxyribose. When incorporated in an oligonucleotide, the compounds have a detrimental influence on duplex stability and on the catalytic activity of hammerhead ribozymes. However, homo-N-nucleosides with a guanine or adenine base moiety do exhibit selective antiviral activity against herpes simplex virus (HSV-1 and HSV-2).
- Subjects :
- biology
Chemistry
Stereochemistry
Oligonucleotide
Guanine
viruses
fungi
Organic Chemistry
Clinical Biochemistry
Ribozyme
Pharmaceutical Science
medicine.disease_cause
Biochemistry
chemistry.chemical_compound
Herpes simplex virus
Duplex (building)
Drug Discovery
biology.protein
medicine
Molecular Medicine
Moiety
Hairpin ribozyme
Molecular Biology
DNA
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi...........e37d2442f0fe5108fb3046ffb8128837