Drugs in the Treatment of Primary Pulmonary Arterial Hypertension

Primary pulmonary arterial hypertension (PPH) should be suspected whenever the following features are present: 1 history of progressive exertional dyspnoea, fatigue and repeated syncopal attacks especially in by young women. 2 physical signs of pulmonary hypertension (increase of intensity of cardiac second sound) often associated with signs of low cardiac output (increase of intensity of cardiac first sound). 3 ECG changes consistent with right ventricular hypertrophy. 4 X-ray evidence of enlargement of right heart cavities and main pulmonary artery with normal left atrium. 5 normal or only slightly altered pulmonary function.