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Comparison of Clostridium botulinum genomes shows the absence of cold shock protein coding genes in type E neurotoxin producing strains
- Source :
- The Botulinum J.. 2:189
- Publication Year :
- 2013
- Publisher :
- Inderscience Publishers, 2013.
-
Abstract
- To collect specific information about the genetic mechanisms that Clostridium botulinum strains utilise when adapting to changing environments, 16 C. botulinum genomes were analysed with comparative genome sequence analysis. Particular attention was paid to low temperature adaptation and the presence of cold shock protein coding genes in these genomes was evaluated. Surprisingly, unlike any other studied strains, the type E neurotoxin-producing strains lacked these extremely conserved genes. This finding suggests unique mechanisms for the cold tolerance of these strains and offers a new perspective into the investigations concerning this subject. The sizes of the pangenome and core genome of a certain bacterial species are considered to reflect the
- Subjects :
- Comparative genomics
Genetics
0303 health sciences
030306 microbiology
Cold tolerance
Biology
Cold-shock domain
medicine.disease_cause
Biochemistry
Genome
03 medical and health sciences
Cellular and Molecular Neuroscience
medicine
Neurotoxin
Clostridium botulinum
General Pharmacology, Toxicology and Pharmaceutics
Adaptation
Gene
030304 developmental biology
Subjects
Details
- ISSN :
- 17547326 and 17547318
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- The Botulinum J.
- Accession number :
- edsair.doi...........e1854b51a5a7d84461b6c63e86330257