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Dual color triads: synthesis, photophysics and applications in live cell imaging
- Source :
- New Journal of Chemistry. 45:9984-9994
- Publication Year :
- 2021
- Publisher :
- Royal Society of Chemistry (RSC), 2021.
-
Abstract
- Fluorescent labels and probes constitute an important class of organic materials used in the development of sensor systems and imaging platforms for various chemical and molecular biology applications. In the development of fluorescent labels and probes, multichromic environment-sensitive fluorophores are very important. In this work, novel triad systems, including subphthalocyanine, BODIPY and thiophene/thianaphthene units, were prepared and their molecular structures were identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and 1H and 13C NMR spectroscopy. The optical properties of the subphthalocyanine–BODIPY–thiophene/thianaphthene triads were determined using UV-vis absorption and fluorescence (2D and 3D) spectroscopic methods and quantum chemical calculations. The data were analyzed by comparing the results of the final properties to those of the BODIPY- and subphthalocyanine-alone units. The compounds were also evaluated in live cell imaging using a breast cancer cell line. The novel subphthalocyanine–BODIPY–thiophene/thianaphthene triads displayed dual color emission, which is critically important for the development of novel systems particularly in biomedical applications such as bioimaging and cellular sensor systems.
- Subjects :
- Triad (anatomy)
02 engineering and technology
General Chemistry
010402 general chemistry
021001 nanoscience & nanotechnology
Photochemistry
Laser
Mass spectrometry
01 natural sciences
Fluorescence
Catalysis
0104 chemical sciences
law.invention
chemistry.chemical_compound
medicine.anatomical_structure
chemistry
Live cell imaging
law
Materials Chemistry
Thiophene
medicine
BODIPY
0210 nano-technology
Dual color
Subjects
Details
- ISSN :
- 13699261 and 11440546
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- New Journal of Chemistry
- Accession number :
- edsair.doi...........e151db1f704d7388ca0456f0949aa98a