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Pathological Alterations in the Cerebral

Authors :
H. M. Zimmerman
Asao Hirano
Norwin H. Becker
Source :
Archives of Neurology. 20:300-308
Publication Year :
1969
Publisher :
American Medical Association (AMA), 1969.

Abstract

THE INABILITY of certain materials to pass from the circulation into the parenchyma of the central nervous system (CNS) has been attributed to a special barrier surrounding the entire system—the blood-brain barrier. This barrier is not present around certain other tissue, such as muscle, as evidenced by the fact that the same material freely passes into them. Certain areas of the brain, however, such as the choroid plexus and the area postrema, do not show a blood-brain barrier.1-3In these regions, the capillary endothelium is quite different from the rest of the brain parenchyma in that the endothelial cells are fenestrated and peroxidase has been observed penetrating "diaphragmatic central channels of the pores."3Thus, it seems reasonable to consider that the endothelium of the brain is at least one structural seat of the blood-brain barrier. Indeed, in the case of the barrier to the tracer, horseradish peroxidase, passage

Details

ISSN :
00039942
Volume :
20
Database :
OpenAIRE
Journal :
Archives of Neurology
Accession number :
edsair.doi...........e13f19ce20db007876ace1e98a9c7b6e
Full Text :
https://doi.org/10.1001/archneur.1969.00480090088013