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Exceptional response after metronomic chemotherapy and palliative radiotherapy in castration-resistant prostate cancer: A case report
- Source :
- European Journal of Medical Case Reports. :135-139
- Publication Year :
- 2017
- Publisher :
- Discover STM Publishing Ltd., 2017.
-
Abstract
- Background Castration-resistant prostate cancer (CRPC) has a dismal prognosis. Despite treatment, median survival of these patients is around 12-22 months. Case Presentation In this report, we present the case of a 71-year-old man, with CRPC and painful bone metastases treated with an association of middle-half-body radiotherapy, androgen deprivation therapy (ADT) and cyclophosphamide-based metronomic chemotherapy. Five years after palliative radiotherapy the patient is still receiving metronomic chemotherapy and ADT. He is totally asymptomatic, with undetectable PSA values and negative 18F-Choline-PET/CT. The only side-effect was the development of non-insulin-dependent diabetes. Conclusion This treatment for its tolerability and feasibility, it could be particularly useful in older patients with CRPC. Furthermore, considering the low costs, it could be an important therapeutic option for patients living in low-resourced countries.
- Subjects :
- Oncology
medicine.medical_specialty
business.industry
medicine.medical_treatment
Exceptional Response
urologic and male genital diseases
medicine.disease
Metronomic Chemotherapy
Asymptomatic
Radiation therapy
Androgen deprivation therapy
Prostate cancer
Tolerability
Internal medicine
Diabetes mellitus
medicine
medicine.symptom
business
Subjects
Details
- ISSN :
- 25204998
- Database :
- OpenAIRE
- Journal :
- European Journal of Medical Case Reports
- Accession number :
- edsair.doi...........e1328cb0a43a8a91a565f66dff435cba