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A randomized controlled trial of corticosteroids for pain after transoral robotic surgery
- Source :
- The Laryngoscope. 127:2558-2564
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Objective To determine if an extended perioperative course of corticosteroids will improve pain control following transoral robotic surgery (TORS). Study Design Randomized, double-blind, placebo-controlled trial. Methods Patients undergoing TORS for initial treatment of oropharyngeal squamous cell carcinoma received a single intraoperative dose of 10-mg dexamethasone and then were randomized to receive 8-mg dexamethasone every 8 hours, or placebo, for up to 4 days after surgery. Pain, measured by visual analog scale (VAS), was the primary outcome measure. Secondary outcome measures included length of stay, dysphagia assessments, and complications. Results VAS pain scores were similar between steroid and placebo cohorts on postoperative day (POD) 1, 2, and 7 through 21, although they significantly improved in the steroid cohort on POD 3. The steroid cohort also demonstrated a decreased hospital length of stay (median 1 day) and improvement in diet consistency, as measured by the performance status scale on POD 7 through 21. There was no difference in complications between the steroid and placebo cohorts. Conclusion Extended perioperative corticosteroids after TORS is safe and may allow earlier improvement in diet consistency and decreased length of hospital stay, although postoperative pain appears minimally affected. Level of Evidence 1b. Laryngoscope, 127:2558–2564, 2017
- Subjects :
- medicine.medical_specialty
Performance status
Visual analogue scale
business.industry
Perioperative
Placebo
Dysphagia
Surgery
law.invention
03 medical and health sciences
0302 clinical medicine
Otorhinolaryngology
Randomized controlled trial
law
030220 oncology & carcinogenesis
Anesthesia
Transoral robotic surgery
Cohort
medicine
medicine.symptom
030223 otorhinolaryngology
business
Subjects
Details
- ISSN :
- 0023852X
- Volume :
- 127
- Database :
- OpenAIRE
- Journal :
- The Laryngoscope
- Accession number :
- edsair.doi...........e123a830bca47655850c30f387a5f556