Back to Search Start Over

Genomic analyses inform on migration events during the peopling of Eurasia

Authors :
Pagani, Luca
Lawson, Daniel John
Jagoda, Evelyn
Mörseburg, Alexander
Eriksson, Anders
Mitt, Mario
Clemente, Florian
Hudjashov, Georgi
DeGiorgio, Michael
Saag, Lauri
Wall, Jeffrey D
Cardona, Alexia
Mägi, Reedik
Wilson Sayres, Melissa A
Kaewert, Sarah
Inchley, Charlotte
Scheib, Christiana L
Järve, Mari
Karmin, Monika
Jacobs, Guy S
Antao, Tiago
Iliescu, Florin Mircea
Kushniarevich, Alena
Ayub, Qasim
Tyler-Smith, Chris
Xue, Yali
Yunusbayev, Bayazit
Tambets, Kristiina
Mallick, Chandana Basu
Saag, Lehti
Pocheshkhova, Elvira
Andriadze, George
Muller, Craig
Westaway, Michael C
Lambert, David M
Zoraqi, Grigor
Turdikulova, Shahlo
Dalimova, Dilbar
Sabitov, Zhaxylyk
Sultana, Gazi Nurun Nahar
Lachance, Joseph
Tishkoff, Sarah
Momynaliev, Kuvat
Isakova, Jainagul
Damba, Larisa D
Gubina, Marina
Nymadawa, Pagbajabyn
Evseeva, Irina
Atramentova, Lubov
Utevska, Olga
Ricaut, François-Xavier
Brucato, Nicolas
Sudoyo, Herawati
Letellier, Thierry
Cox, Murray P
Barashkov, Nikolay A
Skaro, Vedrana
Mulahasanovic, Lejla
Primorac, Dragan
Sahakyan, Hovhannes
Mormina, Maru
Eichstaedt, Christina A
Lichman, Daria V
Abdullah, Syafiq
Chaubey, Gyaneshwer
Wee, Joseph TS
Mihailov, Evelin
Karunas, Alexandra
Litvinov, Sergei
Khusainova, Rita
Ekomasova, Natalya
Akhmetova, Vita
Khidiyatova, Irina
Marjanović, Damir
Yepiskoposyan, Levon
Behar, Doron M
Balanovska, Elena
Metspalu, Andres
Derenko, Miroslava
Malyarchuk, Boris
Voevoda, Mikhail
Fedorova, Sardana A
Osipova, Ludmila P
Lahr, Marta Mirazón
Gerbault, Pascale
Leavesley, Matthew
Migliano, Andrea Bamberg
Petraglia, Michael
Balanovsky, Oleg
Khusnutdinova, Elza K
Metspalu, Ene
Thomas, Mark G
Manica, Andrea
Nielsen, Rasmus
Villems, Richard
Willerslev, Eske
Kivisild, Toomas
Metspalu, Mait
Publisher :
Apollo - University of Cambridge Repository

Abstract

High-coverage whole-genome sequence studies have so far focused on a limited number of geographically restricted populations, or been targeted at specific diseases, such as cancer. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for inferring population history and refuelled the debate on the mutation rate in humans. Here we present the Estonian Biocentre Human Genome Diversity Panel (EGDP), a dataset of 483 high-coverage human genomes from 148 populations worldwide, including 379 new genomes from 125 populations, which we group into diversity and selection sets. We analyse this dataset to refine estimates of continent-wide patterns of heterozygosity, long- and short-distance gene flow, archaic admixture, and changes in effective population size through time as well as for signals of positive or balancing selection. We find a genetic signature in present-day Papuans that suggests that at least 2% of their genome originates from an early and largely extinct expansion of anatomically modern humans (AMHs) out of Africa. Together with evidence from the western Asian fossil record, and admixture between AMHs and Neanderthals predating the main Eurasian expansion, our results contribute to the mounting evidence for the presence of AMHs out of Africa earlier than 75,000 years ago.<br />Support was provided by: Estonian Research Infrastructure Roadmap grant no 3.2.0304.11-0312; Australian Research Council Discovery grants (DP110102635 and DP140101405) (D.M.L., M.W. and E.W.); Danish National Research Foundation; the Lundbeck Foundation and KU2016 (E.W.); ERC Starting Investigator grant (FP7 - 261213) (T.K.); Estonian Research Council grant PUT766 (G.C. and M.K.); EU European Regional Development Fund through the Centre of Excellence in Genomics to Estonian Biocentre (R.V.; M.Me. and A.Me.), and Centre of Excellence for Genomics and Translational Medicine Project No. 2014-2020.4.01.15-0012 to EGC of UT (A.Me.) and EBC (M.Me.); Estonian Institutional Research grant IUT24-1 (L.S., M.J., A.K., B.Y., K.T., C.B.M., Le.S., H.Sa., S.L., D.M.B., E.M., R.V., G.H., M.K., G.C., T.K. and M.Me.) and IUT20-60 (A.Me.); French Ministry of Foreign and European Affairs and French ANR grant number ANR-14-CE31-0013-01 (F.-X.R.); Gates Cambridge Trust Funding (E.J.); ICG SB RAS (No. VI.58.1.1) (D.V.L.); Leverhulme Programme grant no. RP2011-R-045 (A.B.M., P.G. and M.G.T.); Ministry of Education and Science of Russia; Project 6.656.2014/K (S.A.F.); NEFREX grant funded by the European Union (People Marie Curie Actions; International Research Staff Exchange Scheme; call FP7-PEOPLE-2012-IRSES-number 318979) (M.Me., G.H. and M.K.); NIH grants 5DP1ES022577 05, 1R01DK104339-01, and 1R01GM113657-01 (S.Tis.); Russian Foundation for Basic Research (grant N 14-06-00180a) (M.G.); Russian Foundation for Basic Research; grant 16-04-00890 (O.B. and E.B); Russian Science Foundation grant 14-14-00827 (O.B.); The Russian Foundation for Basic Research (14-04-00725-a), The Russian Humanitarian Scientific Foundation (13-11-02014) and the Program of the Basic Research of the RAS Presidium “Biological diversity” (E.K.K.); Wellcome Trust and Royal Society grant WT104125AIA & the Bristol Advanced Computing Research Centre (http://www.bris.ac.uk/acrc/) (D.J.L.); Wellcome Trust grant 098051 (Q.A.; C.T.-S. and Y.X.); Wellcome Trust Senior Research Fellowship grant 100719/Z/12/Z (M.G.T.); Young Explorers Grant from the National Geographic Society (8900-11) (C.A.E.); ERC Consolidator Grant 647787 ‘LocalAdaptatio’ (A.Ma.); Program of the RAS Presidium “Basic research for the development of the Russian Arctic” (B.M.); Russian Foundation for Basic Research grant 16-06-00303 (E.B.); a Rutherford Fellowship (RDF-10-MAU-001) from the Royal Society of New Zealand (M.P.C.).

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi...........e0ee191e98d0e8d598d9ecc435d4106f